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A Phase II Study of Rucaparib Monotherapy in Nonmetastatic, Hormone-Sensitive Prostate Cancer Demonstrating “BRCAness” Genotype (ROAR)

By claireoliverharwood

Both germline and somatic BReast CAncer gene (BRCA) mutations are poor prognostic markers in men with localized or metastatic prostate […]

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68Ga-RM2 PET–MRI versus MRI alone for evaluation of patients with biochemical recurrence of prostate cancer: a single-centre, single-arm, phase 2/3 imaging trial

By claireoliverharwood

National Comprehensive Cancer Network guidelines include prostate-specific membrane antigen (PSMA)-targeted PET for detection of biochemical recurrence of prostate cancer. However, […]

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Correlations of response rate and progression-free survival with overall survival in immunotherapy trials for metastatic non-small-cell lung cancer: an FDA pooled analysis

By claireoliverharwood

Radiographic changes might not fully capture the treatment effects of immune checkpoint inhibitors (ICIs). We aimed to assess correlations of […]

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Pfizer’s bet on bispecific antibodies gets a spookily timely endorsement from Nature Review Drug Discovery!

By claireoliverharwood

No sooner had my excitement over Pfizer’s tell-all oncology strategy on their 29th February 2024 innovation day abated from last week, […]

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Development and Independent Validation of a Prognostic Gene Expression Signature Based on RB1, PTEN, and TP53 in Metastatic Hormone-sensitive Prostate Cancer Patients

By claireoliverharwood

Androgen deprivation therapy (ADT) with docetaxel (D) and/or antiandrogen receptor therapies (ARTs) are the standard therapies in metastatic hormone sensitive […]

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Integrating Patient-Reported Outcomes Into Prognostication in Gastroesophageal Cancer: Results of a Population-Based Retrospective Cohort Analysis

By claireoliverharwood

Patient-reported outcomes measures (PROM) are self-reflections of an individual’s physical functioning and emotional well-being. The Edmonton Symptom Assessment Scale (ESAS) […]

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Adding immunotherapy to first-line treatment of advanced and metastatic endometrial cancer

By claireoliverharwood

Immunotherapy has transformed the endometrial cancer treatment landscape, particularly for those exhibiting mismatch repair deficiency (MMRd/MSI-H). A growing body of […]

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Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer

By claireoliverharwood

No treatment has surpassed platinum-based chemotherapy in improving overall survival in patients with previously untreated locally advanced or metastatic urothelial […]

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Two Hematological Markers Predicting the Efficacy and Prognosis of Neoadjuvant Chemotherapy Using Lobaplatin Against Triple-Negative Breast Cancer

By claireoliverharwood

Our previous work indicated that the addition of lobaplatin to combined therapy with taxane and anthracycline can improve the pathological […]

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Brentuximab vedotin with dacarbazine or nivolumab as frontline cHL therapy for older patients ineligible for chemotherapy

By claireoliverharwood

Older patients with advanced-stage classical Hodgkin lymphoma (cHL) have inferior outcomes compared with younger patients, potentially due to comorbidities and […]

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Recent Posts
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  • Is it time for PET-guided therapy in follicular lymphoma?
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